Dr Holly Matthews
School of Science, Engineering & Environment
Current positions
Lecturer
Biography
I hold a BSc (Hons) in Biology with Psychology from Keele University (2009) and an Erasmus-funded MRes from Stockholm University (2009–2010). My early career was shaped by a research position at Keele University with Professor Hilary Hurd, where I explored how mosquito-stage malaria parasites respond to antimalarial drugs (2010–2011).
In 2011, I was awarded a PhD scholarship at the University of Salford under the supervision of Professor Niroshini Nirmalan, where my research focused on drug repositioning strategies to accelerate antimalarial drug discovery (2011–2015).
Over the following eight years, I developed deep expertise in malaria biology and drug discovery through a series of postdoctoral research roles. At Imperial College London (2015–2017), I joined the Baum Lab, investigating therapeutic targets in malaria transmission stages. I then returned to Keele University to work in Dr Catherine Merrick’s lab, where I explored the molecular mechanisms of DNA replication in transmissible malaria forms (2017–2018). Subsequently, I joined Professor Frédéric Tripet’s group as part of the Open Philanthropy-funded Target Malaria Consortium—a global effort to reduce malaria transmission through genetic vector control.
In 2023, I returned to the University of Salford as a Teaching Fellow in the Biomedicine team. In addition to my ongoing interest in infectious disease research, I have developed a parallel passion for pedagogical innovation, supported through LTEC Scholars funding.
Areas of Research
My research focuses on the fundamental biology of the malaria parasite, with a particular emphasis on how different life cycle stages respond to drug treatment. Having gained comprehensive experience across nearly all culturable stages of the parasite, I am uniquely positioned to investigate stage-specific vulnerabilities and adaptive strategies. This experience continues to fuel my interest in stage-specific drug targeting and transmission-blocking interventions.
Complementing my scientific inquiry, I am also engaged in pedagogical research, with a commitment to developing innovative, evidence-based teaching practices. I’m particularly interested in creating dynamic, student-centred learning environments and designing materials that not only engage but also enhance understanding and retention.
I teach across both undergraduate and postgraduate Biomedical Science programmes, with a strong focus on integrating clinical practice and scientific knowledge with professional skill development. As module lead for Level 6 Clinical Immunology, I use a research-led teaching approach to deepen students’ understanding of immune mechanisms in clinical contexts. I also lead the professional development modules: Professional Communication and Translational Research Skills, where I design and deliver curricula that foster scientific literacy, academic reflective practice and career readiness. These modules are essential in preparing students to navigate both academic research and applied biomedical environments with confidence.
At the postgraduate level, I contribute to key MSc modules including Research Design and Delivery, Medical Biotechnology, and Professional Scholarship Skills. Here, I draw on my research expertise to support students in developing advanced methodological skills, critical analysis, scientific literacy. I also supervise both undergraduate and master’s research projects, mentoring students through the entire research process—from project design and ethical approval to data interpretation and dissemination.
My teaching philosophy is rooted in evidence-based pedagogy and a student-centred approach. I strive to create inclusive, engaging learning environments that encourage inquiry, build confidence, and prepare students for future success in both research and professional practice.
Qualifications
-
Doctor of Philosophy
2011 - 2015 -
Scientific Research Training
2009 - 2010 -
BSc (Hons) Biology with Psychology
2006 - 2009
Publications
- Dynamics of DNA Replication during Male Gametogenesis in the Malaria Parasite Plasmodium Falciparum
- A high throughput screen for next-generation leads targeting malaria parasite transmission
- Drug repositioning as a route to anti-malarial drug discovery: preliminary investigation of the in vitro anti-malarial efficacy of emetine dihydrochloride hydrate