Dr. Luma Godoy Magalhaes
School of Science, Engineering and Environment
I joined Professors Michael Lisanti and Federica Sotgia group at the University of Salford as a Postdoctoral Researcher in July 2019. We are interested in the development of new therapies targeting cancer stem cells (CSC), that are believed to play a key role in cancer recurrence and metastasis. Using several high-, medium- and low- throughput in vitro assays we aim to identify new compounds or repurposable drugs targeting CSC and elucidate its mode of action.
Prior to that, I completed my PhD in Science at the University of Sao Paulo in 2019, supervised by Professor Adriano Andricopulo. Then, my PhD was aimed at the development of new anti-cancer compounds targeting the protein tubulin. We used a range of cell-based and biochemical assays to assess biological activity and mode of action as well as pharmacokinetic and toxicological assays to assess the drug-like properties of these new compounds.
Also, during my PhD, I was involved in the implementation of the screening cascade for the Lead Optimisation Latin America project from DNDi at the University of Sao Paulo. The main goal there was the development of new drugs for Chagas disease and leishmaniasis.
In 2018 I took a role at the Wellcome Centre of Anti-infectives Research at the Drug Discovery Unit, University of Dundee, under the supervision of Professor Kevin Read, where I had the opportunity to enhance my knowledge and practical skills in drug discovery and assay development. This also allowed me to have experience with a more industrial approach to research.
In 2017 I took a role as Lecturer in Radiological Physics at Atheneu Institute in Brazil and in 2015 I finished my MSc in Physics at University of Sao Paulo where I worked with computational and in vitro approaches for the development of novel anti-cancer candidates.
I received my BSc in Biomolecular Physics in 2012 from the Institute of Physics at the University of Sao Paulo where I developed my multidisciplinary approach in Science.
Areas of research
Drug discovery, Cancer, Infectious diseases, Translational medicine
Development of new therapeutics targeting cancer and tumour recurrence
01. OZSVARI, B.; MAGALHAES, L.G.; LATIMER, J.; KANGASMETSA, J.; SOTIGIA, F.; LISANTI, M.P. A Myristoyl Amide Derivative of Doxycycline Potently Targets Cancer Stem Cells (CSCs) and Prevents Metastasis, without Retaining Antibiotic Activity. Frontiers in Oncology, 2020. *Just accepted
02. SOUZA, M.L.; REZENDE, C.O.; FERREIRA, R.S.; CHAVEZ, R.M.E.; FERREIRA, L.L.G.; SLAFER, B.W.; MAGALHAES, L.G.; KROGH, R.; OLIVA, G.; CRUZ, F.C.; DIAS, L.C.; ANDRICOPULO, A.D. Discovery of Potent, Reversible and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach. Journal of Chemical Information and Modeling, 2019.
03. FERREIRA, R.A.A.; PAULI, I.; SAMPAIO, T.S.; SOUZA, M.L.; FERREIRA, L.L.G.; MAGALHAES, L.G.; REZENDE, C.O.; FERREIRA, R.S.; KROGH, R.; DIAS, L.C.; ANDRICOPULO, A.D. Structure-Based and Molecular Modeling Studies for the Discovery of Cyclic Imides as Reversible Cruzain Inhibitors with Potent Anti-Trypanosoma cruzi Activity. Frontiers in Chemistry, v. 7, p. 1-21. 2019
04. PINTO, MERI EMILI F.; NAJAS, J.Z.G.; MAGALHAES, L.G.; BOBEY, A.F.; MENDONÇA, J.N.; LOPES, N.P.; LEME, F.M.; TEIXEIRA, S.P.; TROVÓ, M.; ANDRICOPULO, A.D.; KOEBACH, J.; GRUBER, C.W.; CILLI, E.M.; BOLZANI, V.S. Inhibition of Breast Cancer Cell Migration by Cyclotides Isolated from Pombalia calceolaria. Journal of Natural Products, v. 81, p. 1203-1208, 2018.
05. MAGALHAES, L. G.; FERREIRA, L.G.; ANDRICOPULO, A.D. Recent Advances and Perspectives in Cancer Drug Design. Annals of the Brazilian Academy of Sciences, v. 90, p. 1233 -1250. 2018
06. MAGALHAES, L.G.; MARQUES, F.B.; FONSECA, M.B.; ROGERIO, K.R.; GRAEBIN, C.S.; ANDRICOPULO, A.D. Discovery of a Series of Acridinones as Novel Mechanism-Based Tubulin Assembly Inhibitors with Anticancer Activity. Plos One, v. 11, p. e0160842, 2016.
07. SANTOS, G.B.; KROGH, R.; MAGALHAES, L.G.; ANDRICOPULO, A. D.; PUPO, M. T.; EMERY, F. S. Semisynthesis of new aphidicolin derivatives with high activity against Trypanosoma cruzi. Bioorganic & Medicinal Chemistry Letters, v. 26, p. 1205-1208, 2016.
08. SUETH-SANTIAGO, V.; MORAES, J.B.B.; SOBRAL, E.S.S; VANNIER-SANTOS, M.A.; FREIRE-DE-LIMA, C.G.; CASTRO, R.N.; MENDES-SILVA, G.P.; DEL CISTIA, C.N.; MAGALHAES, L.G.; ANDRICOPULO, A.D.; SANT´ANNA, C.M.R.; DECOTÉ-RICARDO, D.; FREIRE DE LIMA, M.E. The Effectiveness of Natural Diarylheptanoids against Trypanosoma cruzi: Cytotoxicity, Ultrastructural Alterations and Molecular Modeling Studies. Plos One, v. 11, p. e0162926, 2016.