Dr Gemma Lace-Costigan
Senior Lecturer in Molecular Bioscience
I joined the University of Salford in 2011 as a Biomedicine Teaching Fellow and was promoted to Lecturer in 2013. I am a member of the Salford Institute of Dementia and I am the Postgraduate Tutor for the School of Environment and Life Sciences.
I completed a BSc (Hons) Neuroscience at the University of Leeds before obtaining a PhD in Genomic Medicine at the University of Sheffield where I investigated Tau protein pathogenesis in ageing and dementia.
I remained at the University of Sheffield and was awarded a Sir John Stokes Research Fellowship and continued my ageing and dementia research before moving on to investigate the molecular mechanisms underlying Parkinson’s and Huntington’s disease.
I now lead a dementia research group and teach at both undergraduate and postgraduate levels. I am passionate about public engagement and science communication and I regularly share my research and all things brain related at charity events and science festivals.
I teach on a number of Biomedicine programmes at both undergraduate and postgraduate levels, specifically in the area of neuroscience, human physiology, histology, pathology, genetics and anatomy.
I am a pedagogical researcher interested in inclusive teaching, playful learning methods and technology enhanced learning.
My research involves investigating how brain waste disposal system deficits may contribute to the accumulation of abnormal protein in a number of neurodegenerative disorders including as Alzheimer's disease, Parkinson’s disease and frontotemporal dementia.
I am also interested in the role of glial cells in ageing and dementia and the underlying molecular disturbances that underlie the link between obesity and increased dementia risk.
Qualifications and Memberships
BSc (Hons) Neuroscience (University of Leeds)
PhD Genomic Medicine (University of Leeds)
Postgraduate Certificate in Academic Practice (University of Salford)
Fellow of the Institute of Higher Education
Member of the Salford Institute for Dementia
Member of the British Neuropathological Society
Member of the Alzheimer’s Research UK North West Network
Lace-Costigan, GL (2017). Perceptions of Play: Using Play-Doh to Enhance the Student Experience in Bioscience Higher Education. International Journal of Game-Based Learning, Volume 7, Issue 3, p26-37
Chrissi, N & Wilson, J & munroe, N & Lace-Costigan, G & Currie, N G R (2013) 'Warning! Modelling effective mobile learning is infectious. An example from higher education', in: Mobile learning: How mobile technologies can enhance the learning experience, UCISA, Oxford, UK, pp.11-17. Book Chapter
Nerantzi, C, Lace-Costigan, G, Jackson, R, Currie, N, Despard, C and Peters, L (2013) Tweet-tweet who is there? Using Twitter in teacher education, Madhouse of Ideas, available at http://madhouseofideas.org/?page_id=502
Lace G, Ince PG, Brayne C, Savva GM, Matthews FE, de Silva R, Simpson JE, Wharton SB (2012) Mesial Temporal Astrocyte Tau Pathology in the MRC-CFAS Ageing Brain Cohort. Dementia & Geriatric Cognitive Disorders;34(1):15-24
Wharton SB, Brayne C, Savva GM, Matthews FE, Forster G, Simpson J, Lace G, Ince PG (2011). Epidemiological Neuropathology: The MRC Cognitive Function and Aging Study Experience. Journal of Alzheimers Disease;25(2):359-72.
Simpson JE, Ince PG, Lace G, Forster G, Shaw PJ, Matthews F, Savva G, Brayne C, Wharton SB; on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group (2010) Astrocyte phenotype in relation to Alzheimer-type pathology in the ageing brain. Neurobiology of Aging;31(4):578-90.
Simpson JE, Ince PG, Haynes LJ, Theaker R, Gelsthorpe C, Baxter L, Forster G, Lace GL, Shaw PJ, Matthews FE, Savva GM, Brayne C, Wharton SB; on behalf of the MRC Cognitive Function and Ageing Neuropathology Study Group (2010) Population Variation in Oxidative Stress and Astrocyte DNA Damage in Relation to Alzheimer-type Pathology in the Ageing Brain. Neuropathology and Applied Neurobiology 36(1):25-40.
Lace G, Savva GM, Forster G, de Silva R, Brayne C, Matthews FE, Barclay JJ, Dakin L, Ince PG, Wharton SB; MRC-CFAS. (2009) Hippocampal tau pathology is related to neuroanatomical connections: an ageing population-based study. Brain. 132(Pt 5):1324-34.
Lace G, Forster G, Savva G, Matthews F, Brayne C, De Silva R, Strong MJ, Ince PG, Wharton SB (2009) Variation in 4R and 3R tau isoforms in the ageing population. Conference: 110th Annual Meeting of the British-Neuropathological-Society Location: Inst Child Hlth, London, England Neuropathology and Applied Neurobiology Volume: 35 Pages:19-19
Lace G, Forster G, Savva G, Barclay JJ, Dakin L, Matthews F, Brayne C, De Silva R, Ince PG, Wharton SB (2008) Population variation in tau pathology in the MRC-CFAS neuropathology cohort. Conference: 109th Annual Meeting of the British-Neuropathological-Society Location: Inst Child Hlth, London, England ,Neuropathology and Applied Neurobiology Volume: 34, Supplement:1, Pages:10-11
Simpson JE, Ince PG, Lace G, Forster G, Shaw PJ, Matthews F, Brayne C, Wharton S (2008). Characterisation of astrocytes in relation to Alzheimer-type pathology in the ageing brain using a population-based neuropathology cohort. Conference: 109th Annual Meeting of the British-Neuropathological-Society Location: Inst Child Hlth, London, ENGLAND Neuropathology and Applied Neurobiology Volume: 34, Supplement:1, 1 Pages: 31-31
Lace GL, Wharton SB, Ince PG (2007). A brief history of tau: the evolving view of the microtubule-associated protein tau in neurodegenerative diseases. Clinical Neuropathology.26(2):43-58. Review.