Jeremy Allen

Dr Jeremy Allen

Senior Lecturer in Biomedical Science, Academic Lead for Biomedicine

  • Peel Building Room G45
  • T: +44 (0)161 295 0728
  • E: j.t.allen@salford.ac.uk
  • SEEK: Research profile

Biography

I am currently a Senior Lecturer in Biomedical Science and Academic Lead for Biomedicine at the University of Salford, School of Environment & Life Sciences. Born in Lichfield, England I studied at the University of Keele, England, in two separate periods between 1982 and 1992, completing a BSc in Biology and a PhD investigating the pathophysiology of a pathogenic parasite.  In 1991 I received an MSc in Biotechnology from the University of Newcastle, England.

I joined the School of Postgraduate Medicine at the University Hospitals of North Midlands (Royal Stoke University Hospital), England as an NHS Clinical Scientist and Research Fellow from 1992-2003. I was appointed in 2003 to Lecturer in Biosciences at the University of Salford, gaining a PgCert in Higher Education Practice & Research in 2006. In 2009 I was appointed to Senior Lecturer in Biomedical Science and in 2011 was made a Fellow of the Institute of Biomedical Science (IBMS).

Teaching

As the Academic Lead for Biomedicine I have strategic responsibility for undergraduate programmes in this area including BSc Biomedical Science, BSc Biochemistry, BSc Pharmaceutical Science, BSc Medicinal Chemistry and BSc Chemistry. I have a major role in the teaching and delivery of the IBMS-accredited BSc Biomedical Science and am module leader for Biomedical Science Practice, Pathophysiology, Haematology & Transfusion and Cell Pathology.

I also supervise undergraduate projects on BSc Biomedical Science, postgraduate projects on MSc Biomedical Science,  MSc Molecular Parasitology & Vector Biology, and thesis-led PhD students primarily in the research field of inflammation and fibrosis of chronic degenerative disorders.

Research Interests

I am an active member of the Biomedical Research Centre with research interests focused on investigating the cellular pathology and pathogenesis of host-pathogen interactions, inflammation and fibrosis (Fibrosis & Inflammation Research Group), primarily in collaboration with Dr Lucy Smyth also based at Salford. Findings from some of my studies were the first published to show alterations in connective tissue growth factor (CTGF) expression in human lung from patients with fibrosis and led to a successful funding bid from the British Lung Foundation. Antibody therapy against CTGF is now a realistic possibility.

More recently, to extend the scope of the main research theme, studies have been carried out to examine the interaction between medically important parasites (eg. Schistosoma mansoni) and cells crucial to development of liver fibrosis. Currently, projects are underway to evaluate novel ‘nutriceutical’ (polyunsaturated fatty acids, eg omega-3) anti-inflammatory and anti-fibrotic therapeutics using in vitro models of skeletal muscle and lung fibrosis.

Qualifications and Memberships

BSc (Hons) Biology; University of Keele (1985)

MSc Biotechnology; University of Newcastle-upon-Tyne (1991).

PhD Pathophysiology; University of Keele (1992).

PgCert Higher Education Practice & Research; University of Salford (2006).

FIBMS Fellow of the Institute of Biomedical Science (2011)

Member of: European Respiratory Society, American Thoracic Society, American Physiological Society. British Association for Lung Research. British Society for Parasitology, Physiological Society, Institute of Biomedical Science, International Society for Hepatic Sinusoidal Research.

Publications

Burley, S, Whittingham-Dowd, JK, Allen, JT, Grosset, J and Onambele-Pearson, G 2016, 'The differential hormonal milieu of morning versus evening, may have an impact on muscle hypertrophic potential' , PLoS ONE .

 

 

Mohammed, A, Allen, JT and Rogan, MT 2016, 'Does hydatid cyst fluid from Echinococcus granulosus cysts have any effect on cells involved in fibrosis in cystic echinococcosis?' , Journal of Bacteriology and Parasitology, 7 (5) .

 

 

Magee, P, Pearson, S, Whittingham-Dowd, JK and Allen, JT 2012, 'PPARγ as a molecular target of EPA anti-inflammatory activity during TNF-α-impaired skeletal muscle cell differentiation' , The Journal of Nutritional Biochemistry, 23 (11) , pp. 1440-1448.

 

 

Anthony, BJ, Allen, JT, Li, YS and McManus, DP 2010, 'Hepatic stellate cells and parasite-induced liver fibrosis' , Parasites & Vectors, 3 (1) , p. 60.

 

 

Anthony, BJ, Mathieson, W, de Castro-Borges, W and Allen, JT 2010, 'Schistosoma mansoni: egg-induced downregulation of hepatic stellate cell activation and fibrogenesis' , Experimental parasitology, 124 (4) , pp. 409-420.

 

 

Magee, P, Pearson, S and Allen, J 2008, 'The omega-3 fatty acid, eicosapentaenoic acid (EPA), prevents the damaging effects of tumour necrosis factor (TNF)-alpha during murine skeletal muscle cell differentiation' , Lipids in Health and Disease, 7 (1) , p. 24.

 

 

Kasai, H, Allen, JT, Mason, RM, Kamimura, T and Zhang, Z 2005, 'TGF-beta 1 induces human alveolar epithelial to mesenchymal cell transition (EMT)' , Respiratory Research, 6 (56) .

 

 

Allen, JT and Spiteri, MA 2002, 'Growth factors in idiopathic pulmonary fibrosis: relative roles' , Respiratory Research, 3 (1) , pp. 13-22.

 

 

Bloor, CA, Knight, RA, Kedia, RK, Spiteri, MA and Allen, JT 2001, 'Differential mRNA expression of insulin-like growth factor-1 splice variants in idiopathic pulmonary fibrosis and pulmonary sarcoidosis patients' , American Journal of Respiratory and Critical Care Medicine, 164 (2) , pp. 265-272. Item not available from this repository.

 

 

Magee, P, Pearson, S, Whittingham-Dowd, J and Allen, JT 'PPAR <gamma> as a molecular target of EPA anti-inflammatory activity during TNF-<alpha>-impaired skeletal muscle cell differentiation' , The Journal of Nutritional Biochemistry . (In Press) Item not available from this repository.

 

Burley, S, Whittingham-Dowd, JK, Allen, JT, Grosset, J and Onambele-Pearson, G 2016, 'The differential hormonal milieu of morning versus evening, may have an impact on muscle hypertrophic potential' , PLoS ONE .

 

 

Mohammed, A, Allen, JT and Rogan, MT 2016, 'Does hydatid cyst fluid from Echinococcus granulosus cysts have any effect on cells involved in fibrosis in cystic echinococcosis?' , Journal of Bacteriology and Parasitology, 7 (5) .

 

 

Magee, P, Pearson, S, Whittingham-Dowd, JK and Allen, JT 2012, 'PPARγ as a molecular target of EPA anti-inflammatory activity during TNF-α-impaired skeletal muscle cell differentiation' , The Journal of Nutritional Biochemistry, 23 (11) , pp. 1440-1448.

 

 

Anthony, BJ, Allen, JT, Li, YS and McManus, DP 2010, 'Hepatic stellate cells and parasite-induced liver fibrosis' , Parasites & Vectors, 3 (1) , p. 60.

 

 

Anthony, BJ, Mathieson, W, de Castro-Borges, W and Allen, JT 2010, 'Schistosoma mansoni: egg-induced downregulation of hepatic stellate cell activation and fibrogenesis' , Experimental parasitology, 124 (4) , pp. 409-420.

 

 

Magee, P, Pearson, S and Allen, J 2008, 'The omega-3 fatty acid, eicosapentaenoic acid (EPA), prevents the damaging effects of tumour necrosis factor (TNF)-alpha during murine skeletal muscle cell differentiation' , Lipids in Health and Disease, 7 (1) , p. 24.

 

 

Kasai, H, Allen, JT, Mason, RM, Kamimura, T and Zhang, Z 2005, 'TGF-beta 1 induces human alveolar epithelial to mesenchymal cell transition (EMT)' , Respiratory Research, 6 (56) .

 

 

Allen, JT and Spiteri, MA 2002, 'Growth factors in idiopathic pulmonary fibrosis: relative roles' , Respiratory Research, 3 (1) , pp. 13-22.

 

 

Bloor, CA, Knight, RA, Kedia, RK, Spiteri, MA and Allen, JT 2001, 'Differential mRNA expression of insulin-like growth factor-1 splice variants in idiopathic pulmonary fibrosis and pulmonary sarcoidosis patients' , American Journal of Respiratory and Critical Care Medicine, 164 (2) , pp. 265-272. Item not available from this repository.

 

 

Magee, P, Pearson, S, Whittingham-Dowd, J and Allen, JT 'PPAR <gamma> as a molecular target of EPA anti-inflammatory activity during TNF-<alpha>-impaired skeletal muscle cell differentiation' , The Journal of Nutritional Biochemistry . (In Press) Item not available from this repository.