Ian Goodhead

Dr Ian Goodhead

Lecturer in Infectious Diseases

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After completing my undergraduate degree at the University of Keele in 2001, I moved to Cambridge, where I worked at the Wellcome Trust Sanger Institute for a number of years. Initially sequencing and finishing bacterial and parasite genomes important in human and veterinary health, I moved onto the implementation of new sequencing technologies, some of which are now mainstream.

I left Cambridge in 2007 to undertake a PhD at the University of Liverpool in the molecular genetics and host/parasite interaction of Trypanosoma brucei – a protozoan parasite responsible for “Sleeping Sickness” in sub-Saharan Africa. After some postdoctoral research into bacterial endosymbiosis in the same system, within the vector of the African Trypanosome – the Tsetse fly – I moved to Salford in 2015 to take up a lectureship position. 


I teach on a wide range of modules across most years, mainly on the Human Biology and Infectious Diseases programme and on Masters programmes. The main topics I cover are molecular microbiology and parasitology and genomics. I have a Postgraduate Certificate in Academic Practice and am a Fellow of the Higher Education Academy.

Research Interests

My research focuses on the utilization of next generation sequencing (NGS) technologies to better understand microbial pathogenesis, infection, host/pathogen interaction and the evolution of symbiosis. My recent research interests involve combining multiple “‘omics” strategies, including genomics, transcriptomics, proteomics and metabolomics, to elucidate the genomic architecture of endosymbionts in the context of attenuating pathogenesis and evolving alongside their insect hosts. I have grant funding from the Wellcome Trust (Seed Award), The Royal Society of Tropical Medicine and Hygiene and the Royal Society.

Qualifications and Memberships

Fellow of the Higher Education Academy

PGCAP – University of Salford (2017)

PhD – University of Liverpool (2011)

BSc (Hons) – Keele University (2001)


Antwis RE, Griffiths SM, Harrison XA, Aranega-Bou P, Arce A, Bettridge AS, Brailsford FL, de Menezes A, Devaynes A, Forbes KM, Fry EL, Goodhead I, Haskell E, Heys C, James C, Johnston SR, Lewis GR, Lewis Z, Macey MC, McCarthy A, McDonald JE, Mejia-Florez NL, O’Brien D, Orland C, Pautasso M, Reid WDK, Robinson HA, Wilson K, Sutherland WJ. 2017. Fifty important research questions in microbial ecology. FEMS Microbiol Ecol 93:1–10.

Bronowski C, Mustafa K, Goodhead I, James CE, Nelson C, Lucaci A, Wigley P, Humphrey TJ, Williams NJ, Winstanley C. 2017. Campylobacter jejuni transcriptome changes during loss of culturability in water. bioRxiv. https://doi.org/10.1101/150383

Doudoumis V, Blow F, Saridaki A, Augustinos A, Dyer NA, Goodhead I, Solano P, Rayaisse J-B, Takac P, Mekonnen S. 2017. Challenging the Wigglesworthia, Sodalis, Wolbachia symbiosis dogma in tsetse flies: Spiroplasma is present in both laboratory and natural populations. Sci Rep 7.

Goodhead I, Blow F, Brownridge P, Hughes M, Kenny J, Krishna R, McLean L, Pongchaikul P, Beynon R, Darby AC. 2017. Large scale and significant expression from pseudogenes in Sodalis glossinidius - a facultative bacterial endosymbiont. bioRxiv. https://doi.org/10.1101/124388

Goodhead I, Darby AC. 2015. Taking the pseudo out of pseudogenes. Curr Opin Microbiol 23:102–109.

Noyes HA, Daly D, Goodhead I, Kay S, Kemp SJ, Kenny J, Saccheri I, Schnabel RD, Taylor JF, Hall N. 2015. A simple procedure for directly obtaining haplotype sequences of diploid genomes. BMC Genomics 16:642.

Pieszko M, Weir W, Goodhead I, Kinnaird J, Shiels B. 2015. ApiAP2 Factors as Candidate Regulators of Stochastic Commitment to Merozoite Production in Theileria annulata. PLoS Negl Trop Dis 9:e0003933.

Ilott NE, Heward JA, Roux B, Tsitsiou E, Fenwick PS, Lenzi L, Goodhead I, Hertz-Fowler C, Heger A, Hall N. 2014. Long non-coding RNAs and enhancer RNAs regulate the lipopolysaccharide-induced inflammatory response in human monocytes. Nat Commun 5.

Goodhead I, Capewell P, Bailey JW, Beament T, Chance M, Kay S, Forrester S, MacLeod A, Taylor M, Noyes H, others. 2013. Whole-Genome Sequencing of Trypanosoma brucei Reveals Introgression between Subspecies That Is Associated with Virulence. MBio 4:e00197--13.

Scally A, Dutheil JY, Hillier LW, Jordan GE, Goodhead I, Herrero J, Hobolth A, Lappalainen T, Mailund T, Marques-Bonet T, others. 2012. Insights into hominid evolution from the gorilla genome sequence. Nature 483:169–175.

Fox-Clipsham LY, Carter SD, Goodhead I, Hall N, Knottenbelt DC, May PDF, Ollier WE, Swinburne JE. 2011. Identification of a mutation associated with fatal Foal Immunodeficiency Syndrome in the Fell and Dales pony. PLoS Genet 7:e1002133.

Goodhead IB. 2011. Genomic approaches to understanding host resistance and parasite virulence in Trypanosoma parasites. University of Liverpool.

Goodhead I, Archibald A, Amwayi P, Brass A, Gibson J, Hall N, Hughes MA, Limo M, Iraqi F, Kemp SJ, others. 2010. A comprehensive genetic analysis of candidate genes regulating response to Trypanosoma congolense infection in mice. PLoS Negl Trop Dis 4:e880.

Wilhelm BT, Marguerat S, Goodhead I, Bähler J. 2010. Defining transcribed regions using RNA-seq. Nat Protoc 5:255–266.

Holden MTG, Hauser H, Sanders M, Ngo TH, Cherevach I, Cronin A, Goodhead I, Mungall K, Quail MA, Price C, others. 2009. Rapid evolution of virulence and drug resistance in the emerging zoonotic pathogen Streptococcus suis. PLoS One 4:e6072.

Liti G, Carter DM, Moses AM, Warringer J, Parts L, James SA, Davey RP, Roberts IN, Burt A, Koufopanou V, others. 2009. Population genomics of domestic and wild yeasts. Nature 458:337–341.

Campbell PJ, Stephens PJ, Pleasance ED, O’Meara S, Li H, Santarius T, Stebbings LA, Leroy C, Edkins S, Hardy C, others. 2008. Identification of somatically acquired rearrangements in cancer using genome-wide massively parallel paired-end sequencing. Nat Genet 40:722–729.

Carter DM, Liti G, Moses AM, Parts L, James SA, Davey RP, Roberts IN, Blomberg A, Warringer J, Burt A. 2008. Population genomics of domestic and wild yeasts.

Hertz-Fowler C, Figueiredo LM, Quail MA, Becker M, Jackson A, Bason N, Brooks K, Churcher C, Fahkro S, Goodhead I, others. 2008. Telomeric expression sites are highly conserved in Trypanosoma brucei. PLoS One 3:e3527.

Holt KE, Parkhill J, Mazzoni CJ, Roumagnac P, Weill F-X, Goodhead I, Rance R, Baker S, Maskell DJ, Wain J, others. 2008. High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi. Nat Genet 40:987–993.

Stinear TP, Seemann T, Harrison PF, Jenkin GA, Davies JK, Johnson PDR, Abdellah Z, Arrowsmith C, Chillingworth T, Churcher C. 2008. Insights from the complete genome sequence of Mycobacterium marinum on the evolution of Mycobacterium tuberculosis (Genome Research (2008) 18 (729-741)). Genome Res 18:1681.

Thomson NR, Holden MTG, Carder C, Lennard N, Lockey SJ, Marsh P, Skipp P, O’Connor CD, Goodhead I, Norbertzcak H, Harris B, Ormond D, Rance R, Quail M a, Parkhill J, Stephens RS, Clarke IN. 2008. Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates. Genome Res 18:161–71.

Thomson NR, Holden MTG, Carder C, Lennard N, Lockey SJ, Marsh P, Skipp P, O’Connor CD, Goodhead I, Norbertzcak H, others. 2008. Chlamydia trachomatis: genome sequence analysis of lymphogranuloma venereum isolates. Genome Res 18:161–171.

Wilhelm BT, Marguerat S, Watt S, Schubert F, Wood V, Goodhead I, Penkett CJ, Rogers J, Bähler J. 2008. Dynamic repertoire of a eukaryotic transcriptome surveyed at single-nucleotide resolution. Nature 453:1239–1243.

Baker S, Hardy J, Sanderson KE, Quail M, Goodhead I, Kingsley RA, Parkhill J, Stocker B, Dougan G. 2007. A novel linear plasmid mediates flagellar variation in Salmonella Typhi. PLoS Pathog 3:e59.

Baker S, Holt K, Whitehead S, Goodhead I, Perkins T, Stocker B, Hardy J, Dougan G. 2007. A linear plasmid truncation induces unidirectional flagellar phase change in H:z66 positive Salmonella Typhi. Mol Microbiol 66:1207–1218.

Sebaihia M, Peck MW, Minton NP, Thomson NR, Holden MTG, Mitchell WJ, Carter AT, Bentley SD, Mason DR, Crossman L, others. 2007. Genome sequence of a proteolytic (Group I) Clostridium botulinum strain Hall A and comparative analysis of the clostridial genomes. Genome Res 17:1082–1092.

Berriman M, Ghedin E, Hertz-Fowler C, Blandin G, Renauld H, Bartholomeu DC, Lennard NJ, Caler E, Hamlin NE, Haas B, others. 2005. The genome of the African trypanosome Trypanosoma brucei. Science (80- ) 309:416–422.

Eichinger L, Pachebat JA, Glöckner G, Rajandream M-A, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, others. 2005. The genome of the social amoeba Dictyostelium discoideum. Nature 435:43–57.

Karlyshev A V, Champion OL, Churcher C, Brisson J-R, Jarrell HC, Gilbert M, Brochu D, St Michael F, Li J, Wakarchuk WW, others. 2005. Analysis of Campylobacter jejuni capsular loci reveals multiple mechanisms for the generation of structural diversity and the ability to form complex heptoses. Mol Microbiol 55:90–103.

Hall N, Pain A, Berriman M, Churcher C, Harris B, Harris D, Mungall K, Bowman S, Atkin R, Baker S, others. 2002. Sequence of Plasmodium falciparum chromosomes 1, 3--9 and 13. Nature 419:527–531.